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MS is considered to be an autoimmune disease, although we do not know what triggers it. In addition, researchers have noticed that members of the military have a much higher rate of ALS than the non-military population, but the cause of this statistical finding is unknown.
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However, researchers suggest that a chemical imbalance (high levels of glutamate, a chemical messenger) also may play a role in causing the disease. Scientists don't know what triggers the onset of ALS. However, nine of 10 patients seem to have a spontaneous mutation in their genes that causes production of an unusual protein (ubiquilin2) that is speculated to play a significant role in the cause of the disease. Hereditary factors such as genes are thought to play a significant role in some patients because about one of every 10 patients has inherited the disease. Both affect the body's muscles and nerves.ĪLS is not considered an autoimmune disease, although some researchers theorize that it might be, due in part, to a disorganized immune response. The similarities between these two conditions are that both MS and ALS are so-called neurodegenerative diseases that affect the brain and spinal cord (central nervous system or CNS).Symptoms of ALS progress continually, and result in paralysis, and death a few years after the initial diagnosis. In contrast, ALS destroys the nerve cells (neurons) so that the body cannot communicate with the brain. Many people may have mild symptoms for years with periods of remission. MS is neurodegenerative disease that results in the destruction the protective coating (myelin sheath) on nerves of the CNS (central nervous system), which causes a faulty relay of instructions from the brain to the body.
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However, they have more differences than similarities. They sometimes are confused because they have some similarities.